ea0038p186 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015
Babinsky Valerie N
, Hannan Fadil M
, Nesbit M Andrew
, Hough Alison
, Stewart Michelle
, Joynson Elizabeth
, Hough Tertius A
, Bentley Liz
, Aggarwal Abhishek
, Kallay Eniko
, Wells Sara
, Cox Roger D
, Richards Duncan
, Thakker Rajesh V
The modulation of pancreatic islet mass represents a novel therapeutic approach for the management of diabetes mellitus. G-protein coupled receptors (GPCRs) regulate beta-cell expansion and proliferation, and the objective of this study was to assess whether the calcium-sensing receptor (CaSR), which is an abundantly expressed beta-cell GPCR, may influence islet mass and systemic glucose homeostasis, and thus represent an exploitable drug target in some forms of diabetes. We c...